Folate (active folic acid)

Quatrefolic®

Our capsule

Form

Supplier

Glucosamine salt of (6S)-5-methyltetrahydrofolic acid

Gnosis SpA, Italy

Quatrefolic® is a fourth-generation folate – offering greater stability and bioavailability than older forms commonly used in many supplements⁽¹⁸⁾.
As many as 40–60% of people have a genetic mutation that makes it harder to absorb folic acid. Unlike other forms, Quatrefolic® is well absorbed by everyone⁽²³⁾.
Folic acid supplementation can mask early signs of vitamin B12 deficiency – such as anaemia – while Quatrefolic® does not.
The human body can’t produce or store folate – and folate deficiency is one of the most common nutrient gaps, with wide-reaching health consequences at every stage of life.

	Quatrefolic®	Other brands (including "premium") Folic acid and earlier-generation folates
10% higher bioavailability
Safe and highly stable
Does not mask vitamin B12 deficiency
Biologically active form
Suitable for people with impaired folate absorption

Immunity

Folic acid supports the normal function of the immune system⁽⁴⁾. Scientific studies show that folic acid plays an important role in supporting immunity. A deficiency may contribute to chronic inflammation, which is a precursor to many diseases^{(10, 11, 12)}.
Psychological functions

Folic acid helps reduce tiredness and fatigue⁽³⁾ and supports normal psychological function⁽⁵⁾.
Circulatory system

Folic acid contributes to normal homocysteine metabolism⁽⁶⁾ and supports healthy blood formation⁽⁷⁾. Scientific research shows it may help protect against coronary artery disease, thrombosis, atherosclerosis – and ultimately, heart attack and stroke^{(13, 15, 16, 17, 18, 19)}.
Pregnancy

Folic acid supplementation increases folate levels in the mother. Low maternal folate is a known risk factor for neural tube defects in the developing fetus⁽¹⁰⁾. Folic acid also supports maternal tissue growth during pregnancy⁽⁸⁾. Studies show it can reduce the risk of fetal abnormalities – and related pregnancy complications or miscarriage – by up to 70%^{(18, 20, 21, 22)}.

Science is our standard. Always.

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