Sodium butyrate is a natural compound that supports gut health at the cellular level.
For dietary management in conditions such as:
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Research shows that sodium butyrate is the primary energy source for intestinal epithelial cells (colonocytes). It supports their regeneration and strengthens the intestinal barrier – limiting the passage of unwanted substances into the bloodstream(1,2). Sodium butyrate is often recommended for people with inflammatory bowel diseases such as ulcerative colitis (UC) and Crohn’s disease (CD), as well as for those recovering from chemotherapy, radiotherapy, or C. difficile infections. Studies indicate it may help restore epithelial integrity and balance within the digestive tract(3,9). As the natural production of butyrate in the colon decreases with age – and the mucosal barrier becomes less resilient – supplementation may help support its function(1,2). For this reason, sodium butyrate is particularly recommended for older adults.
Sodium butyrate is produced naturally in the colon through the fermentation of fiber by gut bacteria. Research shows that its intake may help restore microbiota balance in states of dysbiosis(4). Studies also indicate it may curb excessive activity of pro-inflammatory bacteria and support the growth of beneficial species(5). Sodium butyrate is therefore recommended for functional bowel disorders (including IBS, SIBO, IMO) – studies show it may reduce symptoms such as abdominal pain, bloating, and irregular bowel movements(8) – as well as after antibiotic therapy. It is also recommended during periods of prolonged stress, which disrupts the microbiota and weakens the intestinal barrier – research indicates that butyrate may help restore balance in such cases(4,9).
Sodium butyrate may support dietary management of diarrhea of various origins – infectious, post-antibiotic, or related to food intolerances. Studies show it may help shorten the duration of diarrhea and reduce intestinal inflammation(6,7). In cases of irritable bowel syndrome, sodium butyrate may ease symptoms such as abdominal pain, bloating, and irregular bowel movements(8).
Preclinical and clinical studies have shown that sodium butyrate may modulate the inflammatory response – influencing cytokine expression and the activity of the intestinal immune system(9). Sodium butyrate is often recommended for people with inflammatory bowel diseases such as ulcerative colitis (UC) and Crohn’s disease (CD).
Research suggests that sodium butyrate may positively influence digestive comfort – helping reduce bloating, heaviness, and abdominal pain. These benefits may stem from its anti-inflammatory effects, support for the microbiota, and its role in regenerating the intestinal epithelium(8,10). It is therefore recommended for functional bowel disorders (including IBS, SIBO, IMO). Sodium butyrate may also be particularly helpful in cases of low dietary fiber intake, when its natural production in the intestine is reduced – for example, with light, elimination, low-residue, or highly processed diets.
Our Sodium butyrate is a premium-grade ingredient, with purity confirmed by research – free from carriers, preservatives, and unnecessary additives. It is produced in Italy, following current cGMP standards, with strict microbiological and physicochemical control. The patented MATRIS® technology (USA Patent No. 9,333,170 B2) allows for exceptionally high concentrations of the active substance in every capsule – and for gentle, controlled release in the intestine. Microencapsulation and the purity of the manufacturing process ensure better tolerance and help reduce the characteristic intensity of butyrate’s natural odor.
Resistant to stomach acid – dissolves only in the small intestine, protecting the contents from premature release.
Each sodium butyrate particle is coated with a thin polymer layer, allowing for gradual release in the intestine.
Ingredients
Chemical form
Quantity (in 1 capsule)
Quantity (in 2 capsules)
Microencapsulated sodium butyrate
Other ingredients: capsule shell (hypromellose, gellan gum), aromatic insert (natural orange oil).
Nutritional value (100 g / 2 capsules / 1 capsule): energy value 0 kcal / 0 kcal / 0 kcal, fat (of which saturates) 0 g / 0 g / 0 g (0 g / 0 g / 0 g), carbohydrates (of which sugars) 0 g / 0 g / 0 g (0 g / 0 g / 0 g), fiber 0 g / 0 g / 0 g, protein 0 g / 0 g / 0 g, salt (sodium) 0.18 g / 0.11 g / 0.05 g.
Recommended intake: adults: 1 capsule twice per day; children 7+ years: 1 capsule per day. Capsules should be swallowed whole, without chewing or opening, after a meal, with water.
Storage: Keep the product sealed, at 15-25℃, in a dry, dark place, out of reach of young children. Consume within 2 months after opening.
Important information: This product should be used under medical supervision. It is an incomplete food and must not be used as the sole source of nutrition. Do not use in individuals with swallowing difficulties. Not recommended during pregnancy or breastfeeding. Capsules must not be chewed or opened, and should not be left in the mouth to dissolve. This product is not intended for parenteral use. The aromatic insert is not intended for consumption.
"Imbalances in the gut microbiota are still often an underestimated starting point for many health issues. This is why mindful, daily care for its balance is so important."
Dr. Nina Nicheska, founder of nikalab
Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008 Jan 15;27(2):104-19. doi: 10.1111/j.1365-2036.2007.03562.x. Epub 2007 Oct 25. PMID: 17973645.
Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011 Mar 28;17(12):1519-28. doi: 10.3748/wjg.v17.i12.1519. PMID: 21472114; PMCID: PMC3070119.
Ferreira TM, Leonel AJ, Melo MA, Santos RR, Cara DC, Cardoso VN, Correia MI, Alvarez-Leite JI. Oral supplementation of butyrate reduces mucositis and intestinal permeability associated with 5-Fluorouracil administration. Lipids. 2012 Jul;47(7):669-78. doi: 10.1007/s11745-012-3680-3. Epub 2012 May 31. PMID: 22648862.
Ríos-Covián D, Ruas-Madiedo P, Margolles A, Gueimonde M, de Los Reyes-Gavilán CG, Salazar N. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol. 2016 Feb 17;7:185. doi: 10.3389/fmicb.2016.00185. PMID: 26925050; PMCID: PMC4756104.
Louis P, Flint HJ. Formation of propionate and butyrate by the human colonic microbiota. Environ Microbiol. 2017 Jan;19(1):29-41. doi: 10.1111/1462-2920.13589. Epub 2016 Dec 8. PMID: 27928878.
Di Sabatino A, Morera R, Ciccocioppo R, Cazzola P, Gotti S, Tinozzi FP, Tinozzi S, Corazza GR. Oral butyrate for mildly to moderately active Crohn's disease. Aliment Pharmacol Ther. 2005 Nov 1;22(9):789-94. doi: 10.1111/j.1365-2036.2005.02639.x. PMID: 16225487.
Banasiewicz T, Krokowicz Ł, Stojcev Z, Kaczmarek BF, Kaczmarek E, Maik J, Marciniak R, Krokowicz P, Walkowiak J, Drews M. Microencapsulated sodium butyrate reduces the frequency of abdominal pain in patients with irritable bowel syndrome. Colorectal Dis. 2013 Feb;15(2):204-9. doi: 10.1111/j.1463-1318.2012.03152.x. PMID: 22738315.
Segain JP, Raingeard de la Blétière D, Bourreille A, Leray V, Gervois N, Rosales C, Ferrier L, Bonnet C, Blottière HM, Galmiche JP. Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease. Gut. 2000 Sep;47(3):397-403. doi: 10.1136/gut.47.3.397. PMID: 10940278; PMCID: PMC1728045.
Fachi JL, Felipe JS, Pral LP, da Silva BK, Corrêa RO, de Andrade MCP, da Fonseca DM, Basso PJ, Câmara NOS, de Sales E Souza ÉL, Dos Santos Martins F, Guima SES, Thomas AM, Setubal JC, Magalhães YT, Forti FL, Candreva T, Rodrigues HG, de Jesus MB, Consonni SR, Farias ADS, Varga-Weisz P, Vinolo MAR. Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism. Cell Rep. 2019 Apr 16;27(3):750-761.e7. doi: 10.1016/j.celrep.2019.03.054. PMID: 30995474.
Rosa L, Cutone A, Lepanto MS, Paesano R, Valenti P. Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis. Int J Mol Sci. 2017 Sep 15;18(9):1985. doi: 10.3390/ijms18091985. PMID: 28914813; PMCID: PMC5618634.
Huang, Y., Zhang, P., Han, S., & He, H. (2023). Lactoferrin Alleviates Inflammation and Regulates Gut Microbiota Composition in H5N1-Infected Mice.Nutrients,15(15), 3362.
Fernandes KE, Carter DA. The Antifungal Activity of Lactoferrin and Its Derived Peptides: Mechanisms of Action and Synergy with Drugs against Fungal Pathogens. Front Microbiol. 2017 Jan 18;8:2. doi: 10.3389/fmicb.2017.00002. PMID: 28149293; PMCID: PMC5241296.
Kell DB, Heyden EL, Pretorius E. The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria. Front Immunol. 2020 May 28;11:1221. doi: 10.3389/fimmu.2020.01221. PMID: 32574271; PMCID: PMC7271924.
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