What effects can you expect by taking the Everyday Base for women 18-49?

Everyday base for women 18-49  years was developed to provide the necessary support for your body so that you feel full of strength to face everyday challenges. It includes:

• acids Omega-3 from algae (DHA+EPA),
• vitamin D3 from algae (cholecalciferol) , 
• vitamin B12 (methylcobalamin),
• folate – active folic acid (glucosamine salt of (6s)-5-methyltetrahydrofolic acid),
• choline (choline bitartrate).

These ingredients are included because it is difficult to provide them in the right amount in the diet, and the benefits of their supplementation have been supported by scientific research. Together with doctors and scientists, we have developed the appropriate composition of the Base, the type of capsule, the form of active ingredients and we have selected the doses so that nikalab supplements are not only effective, but also safe . You can take our products every day to enjoy good health and well-being, efficient functioning of the heart, brain and thyroid gland, as well as radiant skin, strong hair and nails. Let's take a closer look at how the ingredients contained in Database , they may affect your body.

Immune support.

A well-functioning immune system is needed to fight infections. Its work is regulated, among others, by: vitamin D. Providing the right amount of this vitamin with your diet is practically impossible (read more about it in a separate article ), so supplementation is necessary. Included in the nikalab Database vitamin D3, and also acids Omega-3 will provide solid support because they ensure the good condition of the immune system and inhibit inflammatory processes ^1,2,3 . They can also prevent the development of autoimmune diseases ^4.5 . Less obvious, but scientifically proven positive effects on immunity will also be found in the Database active folic acid and methylated vitamin B12 . Their deficiency may cause chronic inflammation, which is a precursor of many diseases ^6.7 .

Better sleep and mood, less stress.

Mentioned above vitamin D it is also the guardian of our mental health. Its low level is related to poor well-being and symptoms of depression and stress ^8,9 . Together with vitamin D, it is responsible for mood vitamin B12 ¹⁰ . Taking it may also be helpful in the treatment of depression ¹¹ . Additionally, vitamin B12 helps in production sleep hormone (melatonin) ¹² and normalizes the circadian rhythm ^13,14 . Acids also have a beneficial effect on sleep Omega-3 ^15,16 . That's why we combined the mentioned ingredients in ours Everyday basis for women 18-49 years old .

Improving memory and concentration.

Contained in our products choline plays an important role in brain function and supports cognitive functions ¹⁷ . Her allies in this difficult task are Omega-3 fatty acids and vitamin B12 , which support concentration, learning and memory ^18,19,20 . All these 3 ingredients and also active folic acid and vitamin D3 influence the functioning of neurons. Research shows that they delay brain aging and are able to reduce the risk of neurodegenerative diseases:

• Alzheimer's disease (Omega-3 ^21.22 )
• Parkinson's disease (vitamin D3 ²³ )
• dementia (Omega-3 ²⁴ , folic acid ²⁵ ).

More energy every day and better performance.

Thanks to receiving Everyday bases from nikalab you can increase your efficiency and fight the feeling of constant fatigue that accompanies many women. We try to combine family responsibilities with work, not forgetting about our social life, but very often we simply collapse after 6 p.m., having no energy to train, play with our children, or go out. Scientific research shows that we need sufficient levels to sustain energy folic acid ^26,27 i vitamin B12 ²⁸ . If we want to further increase our physical performance, achieve better results during training and recover faster after exercise, they are also necessary vitamin D3 ²⁹ , Omega-3 fatty acids ^30.31 and choline ³² . You will find all these ingredients in our Database.

A healthier heart and balanced cholesterol levels.

Cardiovascular diseases are the most common cause of mortality in the world. And if we think that they can only affect us in retirement, we are wrong. These diseases are also widespread among young people, including: for the reason that we are not aware of their risks ³³ . As we know, prevention is better than cure, so it is worth making sure to include substances in your diet that are recognized by scientists as beneficial for the heart and blood vessels , and also help maintain proper functioning cholesterol level . Research shows that the ingredients contained in Everyday basis for women 18-49 years old are capable of:

• maintaining optimal lipid profile (Omega-3 ³⁴ , vitamin B12 ³⁵ ),
• reinforcements performance cardiovascular (Omega-3 ³⁶ ),
• protection against coronary heart disease, thrombosis, atherosclerosis and other diseases circulatory system (folic acid ³⁷ , choline ³⁸ , vitamin B12 ³⁹ ),
• reducing risk heart attack and stroke (Omega-3 ⁴⁰ , folic acid ⁴¹ , choline ⁴² ),
• they also help in fat metabolism and efficient functioning liver (choline ⁴³ ).

Additionally, the Base contains methylated vitamin B12 and active folic acid they also support the process blood formation in our body ^44.45 .

Better skin, stronger hair and nails.

Omega-3 fatty acids contained in the Base take care of the overall condition of the skin. They prevent and support the fight against imperfections ⁴⁶ . In turn, the condition of hair and nails depends on the efficient functioning of the thyroid gland Niklab database supports thanks to the content of vitamin D3.

Stronger bones, more efficient joints and muscles.

The vitamin D3 from algae contained in the nikalab Base supports absorption and use of calcium and phosphorus , which contributes to maintaining healthy bones and joints, as well as better muscle functioning ^47.48 .

Preparation for pregnancy.

If you are considering expanding your family, ingredients Databases for women aged 18-49 from nikalab combined with a varied diet, they will help you reduce the risk of nutritional deficiencies. It is worth balancing them before conception occurs. The health of the future pregnant woman directly affects the health of the future child . Our Database will also be good support in the early stages of pregnancy, when you don't know about it yet. In addition to other ingredients important for maintaining pregnancy and the health of the fetus, the Base also contains active folic acid. Until o 70% reduces risk of fetal neural tube development defects (resulting in, among others, spina bifida) ^49,50,51 . However, once you are sure that you are expecting a baby, switch to Base for pregnant women - Two . Its composition was developed with the needs of an increasingly rapidly developing baby and future mother in mind. You can read about the health benefits it provides in a separate article .

Breastfeeding women will also benefit from taking Baza every day. The ingredients it contains will help support the mother's body and the child's brain development.

And moreover…

Base Ingredients lower the risk of some cancers – among others large intestine ⁵² or breast cancer ⁵³ and help protect eye health ⁵⁴ .

All active substances Databases for women aged 18-49 they are in the most digestible forms for the body, and also come from carefully selected suppliers from Europe ( you can find a map here ). To make the ingredients better absorbed and supplementation more convenient, we combined them based on innovative technologies (you can read about what makes our capsule stand out in a separate article ).

When will you see the results?

When you start using Everyday base from nikalab , your body will undergo changes that you may not feel immediately. Each of us is different, so we also need a different amount of time to start reaping the benefits of supplementation. After a few months, you will probably start to appreciate its effects.

Your immune system will better fight viruses and bacteria, and you may also notice improvements in your mood, sleep and performance throughout the day. Internal changes will also affect your appearance . You can expect better skin condition, stronger hair and nails.

Your fullest potential Everyday base will achieve in the long term. Combined with a varied diet and physical activity, supplementation will allow you to feel and look better, have more energy, sleep better and enjoy health.

To benefit from the above-described benefits of Omega-3 fatty acids and vitamins, we recommend taking daily 2 capsules Databases for women aged 18-49 at once, at any time, with or without food. Remember, however, that effective supplementation must be consistent and should not replace a varied diet (why is this so, you will read here ).

Bibliography:

1. Gutierrez S. et al., “Effects of omega-3 fatty acids on immune cells.” Intl J Mol Sci., vol. 20, no. 20, pg. 5028, 2019
2. Calder, PC et al., “Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections.” Nutrients., vol. 12 no. 1181, 2020
3. Basil MC, Levy BD, “Specialized pro-resolving mediators: endogenous regulators of infection and inflammation.” Nature Reviews, Immunology, vol. 16, pp. 51-67, 2016.
4. Grant WB, Lahore H, Rockwell MS, “The Benefits of Vitamin D Supplementation for Athletes: Better Performance and Reduced Risk of COVID-19”, Nutrients. 2020
5. EFSA Journal 2015;13(5):4096. Scientific Opinion on the substance of a health claim related to vitamin D and contribution to the normal function of the immune system.
6. Dhur A., ​​Galan P., Hercberg S., “Folate status and the immune system”, Prog Food Nutr Sci. 1991;15(1-2):43-60.
7. Mikkelsen K., Apostolopoulos V., "Vitamin B12, Folic Acid, and the Immune System", [in:] Nutrition and Immunity, Victoria University Melbourne, pp. 103-114, 2019.
8. Wilkins CH et al., “Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults,” Am J Geriatr Psychiatry. 2006
9. Nair R., Maseeh A., “Vitamin D: The “sunshine” vitamin.” J Pharmacol Pharmacother. 2012
10. Leishear K. et al., “Relationship between vitamin B 12 and sensory and motor peripheral nerve function in older adults.” Journal of the American Geriatrics Society, 2012.
11. Syed EU, Wasay M., Awan S., “Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial.” The open neurology journal, 7, 44, 2013.
12. Honma K. et al., “Effects of vitamin B12 on plasma melatonin rhythm in humans: increased light sensitivity phase-advances the circadian clock?” Experientia, 1992
13. Mayer G., Kröger M., Meier-Ewert K., “Effects of vitamin B12 on performance and circadian rhythm in normal subjects”, Neuropsychopharmacology, 1996.
14. Okawa M. et al., “Vitamin B12 treatment for sleep-wake rhythm disorders,” Sleep. 1990
15. Gross D. et al., “Dietary fish intake and sleep quality: a population-based study.” Sleep Med., vol. 17, pg. 126-128, 2016
16. Montgomery P. et al., “Fatty acids and sleep in UK children: objective and pilot objective sleep results from the DOLAB study – a randomized controlled trial.” J Sleep Res., vol. 23, no. 4, pg. 364-388, 2014
17. Derbyshire E., Obeid R.,"Choline. Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days.” Nutrients, June 2020
18. EFSA Journal 2010;8(10):1796. Scientific Opinion on the substance of health claims related to eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA).
19. Yurko-Mauro K. et al., “Docosahexaenoic acid and adult memory: a systematic review and meta-analysis,” PLoS One. 2015
20. Köbe T. et al., “Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment.” Am J Clin Nutr. 2016
21. Fotuhi M. et al., “Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association,” Review Nat Clin Pract Neurol. 2009
22. Schaefer EJ et al., “Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study,” Arch Neurol. 2006
23. Knekt P. et al., “Serum vitamin D and the risk of Parkinson disease,” Arch Neurol. 2010
24. Yurko-Mauro K. et al., “Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline,” Alzheimers Dement. 2010
25. Reynolds EH, “Folic acid, aging, depression, and dementia.” BMJ. 2002
26. Jacobson W., "Serum folate and chronic fatigue syndrome", Neurology, 1993.
27. EFSA Journal 2010;8(10):1760. Scientific Opinion on the substance of health claims related to folate and contribution to normal psychological functions, maintenance of normal vision, reduction of tiredness and fatigue, cell division and contribution to normal amino acid synthesis.
28. Köbe T. op.cit.
29. Grant WB et al., “The Benefits of Vitamin D Supplementation for Athletes: Better Performance and Reduced Risk of COVID-19,” Nutrients. 2020
30. Philpott JD, Witard OC, Galloway SDR, “Applications of omega-3 polyunsaturated fatty acid supplementation for sport performance.” Res Sports Med. 2019
31. Macartney MJ, Hingley L., Brown MA et al., “Intrinsic heart rate recovery after dynamic exercise is improved with an increased omega-3 index in healthy males.” Br J Nutr. 2014
32. Zeisel SH, “Choline: Human Requirements and Effects on Human Performance”, Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations, Institute of Medicine (USA) Committee on Military Nutrition Research; National Academies Press (USA); 1994
33. Surma S., Szyndler A., ​​Narkiewicz K., "Awareness of selected risk factors for cardiovascular diseases in the population of young people." Heart and Vascular Diseases, Volume 14, No. 4 (2017).
34. Skulas-Ray AC et al., “American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.” Circulation. 2019
35. Adaikalakoteswari A. et al., “Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes,” Clin Epigenetics. 2015
36. EFSA Journal 2010;8(10):1796. Scientific Opinion on the substance of health claims related to eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA).
37. Wang Y. et al., “The effect of folic acid in patients with cardiovascular disease. A systematic review and meta-analysis”, Medicine (Baltimore). 2019
38. EFSA Journal 2011;9(4):2056. Scientific Opinion on the substance of health claims related to choline and contribution to normal lipid metabolism, maintenance of normal liver function, contribution to normal homocysteine ​​metabolism, maintenance of normal neurological function, contribution to normal cognitive function, and brain and neurological development.
39. EFSA Journal 2010;8(10):1756. Scientific Opinion on the substance of health claims related to vitamin B12 and contribution to normal neurological and psychological functions, contribution to normal homocysteine ​​metabolism, maintenance of normal bone, maintenance of normal teeth, maintenance of normal hair, maintenance of normal skin, maintenance of normal nails, reduction of tiredness and fatigue, and cell division.
40. Skulas-Ray AC, op.cit.
41. Tian T. et al., “Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease,” Am J Med Sci. 2017
42. Millard HR et al., “Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study. Eur J Nutr. 2018
43. Mehedint MG, Zeisel SH, “Choline's role in maintaining liver function: new evidence for epigenetic mechanisms.” Curr Opin Clin Nutr Metab Care. 2013
44. Koury MJ, Ponka P., “New insights into erythropoiesis: the roles of folate, vitamin B12, and iron.” Annu Rev Nutr. 2004
45. EFSA Journal, “Scientific Opinion on the substance of health claims related to vitamin B12 and contribution to normal neurological and psychological functions, contribution to normal homocysteine ​​metabolism, maintenance of normal bone, maintenance of normal teeth, maintenance of normal hair, maintenance of normal skin "maintenance of normal nails, reduction of tiredness and fatigue, and cell division", 2010.
46. Balić A. et al., “Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases”, Int J Mol Sci. 2020
47. Laird E., Ward M., McSorley E., Strain JJ, Wallace J., “Vitamin D and bone health: potential mechanisms.” Nutrients. 2010
48. Lips P., van Schoor NM, “The effect of vitamin D on bone and osteoporosis.” Best Pract Res Clin Endocrinol Metab. 2011
49. LE Martínez-Garza, “Twenty-five years of knowledge of the prevention of neural tube defects with folic acid.” Editorial. October - December 2016.
50. Lamers Y. et al., “Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age.” Am J Clin Nutr. 2006
51. Seremak-Mrozikiewicz A. et al., “The significance of 1793G>A polymorphism in MTHFR gene in women with first trimester recurrent miscarriages.” Neuro Endocrinol Lett. 2010
52. Theodoratou E., McNeill G., Cetnarskyj R. et al., “Dietary fatty acids and colorectal cancer: a case-control study.” Am J Epidemiol. 2007
53. Fabian CJ, Kimler BF, Hursting SD, “Omega-3 fatty acids for breast cancer prevention and survivorship.” Breast Cancer Res 17, 62 (2015).
54. Millen AE, Voland R., Sondel SA, “Vitamin D status and early age-related macular degeneration in postmenopausal women.”CAREDS Study Group, Arch Ophthalmol. 2011